PPFIA1

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Description

PTPRF interacting protein alpha 1

Tissue specificity

Low tissue specificity

Subcell location

Focal adhesion sites, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (70270690 - 70385312)

Ensembl ID

ENSG00000131626  (ver. 103.38)

Orthologs

Mouse Ppfia1: ENSMUSG00000037519

UniProt

Q13136

neXtProt

NX_Q13136

Human splice variants
Mouse splice variants

Protein structure