MAGEA10

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene. [provided by RefSeq, Oct 2011]

Description

MAGE family member A10

Tissue specificity

Group enriched (placenta, testis)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (152133310 - 152138578)

Ensembl ID

ENSG00000124260  (ver. 103.38)

Orthologs

-

UniProt

P43363

neXtProt

NX_P43363

Human splice variants

Protein structure