KCNC4

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Description

Potassium voltage-gated channel subfamily C member 4

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoli, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Voltage-gated ion channels

Chromosome

1 (110210314 - 110283100)

Ensembl ID

ENSG00000116396  (ver. 103.38)

Orthologs

Mouse Kcnc4: ENSMUSG00000027895

UniProt

Q03721

neXtProt

NX_Q03721

Human splice variants
Mouse splice variants

Protein structure