YTHDF2

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

Description

YTH N6-methyladenosine RNA binding protein 2

Tissue specificity

Low tissue specificity

Subcell location

Cytosol, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (28736621 - 28769775)

Ensembl ID

ENSG00000198492  (ver. 103.38)

Orthologs

Mouse Ythdf2: ENSMUSG00000040025

UniProt

Q9Y5A9

neXtProt

NX_Q9Y5A9

Human splice variants
Mouse splice variants

Protein structure