DNAJB13

This gene encodes a member of the heat shock protein 40 co-chaperone family which is produced in large amounts in the testis and is located on the radial spokes of the axoneme in human sperm flagella and other flagellar structures. The encoded protein associates with the sperm annulus, as part of the septin complex, through direct interaction with septin 4, during sperm terminal differentiation. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and male infertility. [provided by RefSeq, Apr 2017]

Description

DnaJ heat shock protein family (Hsp40) member B13

Tissue specificity

Tissue enhanced (fallopian tube, testis)

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (73951026 - 73970366)

Ensembl ID

ENSG00000187726  (ver. 103.38)

Orthologs

Mouse Dnajb13: ENSMUSG00000030708

UniProt

P59910

neXtProt

NX_P59910

Human splice variants
Mouse splice variants

Protein structure