CPN1

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

Description

Carboxypeptidase N subunit 1

Tissue specificity

Tissue enriched (liver)

Predicted location

Intracellular, Secreted to blood

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (100042193 - 100081869)

Ensembl ID

ENSG00000120054  (ver. 103.38)

Orthologs

Mouse Cpn1: ENSMUSG00000025196

UniProt

P15169

neXtProt

NX_P15169

Human splice variants
Mouse splice variants

Protein structure