KCNA4

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential. [provided by RefSeq, Mar 2011]

Description

Potassium voltage-gated channel subfamily A member 4

Tissue specificity

Group enriched (adrenal gland, brain)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

11 (30009730 - 30017030)

Ensembl ID

ENSG00000182255  (ver. 103.38)

Orthologs

Mouse Kcna4: ENSMUSG00000042604

UniProt

P22459

neXtProt

NX_P22459

Human splice variants
Mouse splice variants

Protein structure