SLC26A5

This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Description

Solute carrier family 26 member 5

Tissue specificity

Tissue enhanced (brain)

Predicted location

Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Transporters

Chromosome

7 (103352730 - 103446207)

Ensembl ID

ENSG00000170615  (ver. 103.38)

Orthologs

Mouse Slc26a5: ENSMUSG00000029015

UniProt

P58743

neXtProt

NX_P58743

Human splice variants
Mouse splice variants

Protein structure