OAS2

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

2'-5'-oligoadenylate synthetase 2

Tissue specificity

Tissue enhanced (salivary gland)

Subcell location

Centrosome

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (112978395 - 113011723)

Ensembl ID

ENSG00000111335  (ver. 103.38)

Orthologs

Mouse Oas2: ENSMUSG00000032690

UniProt

P29728

neXtProt

NX_P29728

Human splice variants
Mouse splice variants

Protein structure