PHF7

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Description

PHD finger protein 7

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

3 (52410660 - 52423641)

Ensembl ID

ENSG00000010318  (ver. 103.38)

Orthologs

Mouse Phf7: ENSMUSG00000021902

UniProt

Q9BWX1

neXtProt

NX_Q9BWX1

Human splice variants
Mouse splice variants

Protein structure