RASAL1

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Description

RAS protein activator like 1

Tissue specificity

Tissue enhanced (parathyroid gland, salivary gland)

Subcell location

Plasma membrane, Cell Junctions, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

12 (113098819 - 113136239)

Ensembl ID

ENSG00000111344  (ver. 103.38)

Orthologs

Mouse Rasal1: ENSMUSG00000029602

UniProt

O95294

neXtProt

NX_O95294

Human splice variants
Mouse splice variants

Protein structure