CTAG2

This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Description

Cancer/testis antigen 2

Tissue specificity

Tissue enhanced (heart muscle, testis)

Subcell location

Nucleoplasm, Nuclear bodies, Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (154651972 - 154653579)

Ensembl ID

ENSG00000126890  (ver. 103.38)

Orthologs

-

UniProt

O75638

neXtProt

NX_O75638

Human splice variants

Protein structure