ARHGAP35

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

Description

Rho GTPase activating protein 35

Tissue specificity

Low tissue specificity

Subcell location

Nuclear bodies, Aggresome

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (46860997 - 47005077)

Ensembl ID

ENSG00000160007  (ver. 103.38)

Orthologs

Mouse Arhgap35: ENSMUSG00000058230

UniProt

Q9NRY4

neXtProt

NX_Q9NRY4

Human splice variants
Mouse splice variants

Protein structure