BCL7A

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

BAF chromatin remodeling complex subunit BCL7A

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (122019422 - 122062044)

Ensembl ID

ENSG00000110987  (ver. 103.38)

Orthologs

Mouse Bcl7a: ENSMUSG00000029438

UniProt

Q4VC05

neXtProt

NX_Q4VC05

Human splice variants
Mouse splice variants

Protein structure