ZCCHC8

This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]

Description

Zinc finger CCHC-type containing 8

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (122471599 - 122501073)

Ensembl ID

ENSG00000033030  (ver. 103.38)

Orthologs

Mouse Zcchc8: ENSMUSG00000029427

UniProt

Q6NZY4

neXtProt

NX_Q6NZY4

Human splice variants
Mouse splice variants

Protein structure