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RSPO1
R-spondin 1FLJ40906, RSPONDIN
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Top validated antibodies |
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| Novus Biologicals |  NBP1-77354 |
1 references | Polyclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX85282 |
Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN615699 |
4 references | Polyclonal |
WB
IHC
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| Boster Biological Technology | A02857-1 |
Polyclonal |
WB
EL
ICC
IHC
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| R&D Systems | AF3474 |
5 references | Polyclonal |
WB
IHC
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