ADRA2A

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]

Description

Adrenoceptor alpha 2A

Tissue specificity

Tissue enhanced (adipose tissue, cervix)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

10 (111077029 - 111080907)

Ensembl ID

ENSG00000150594  (ver. 103.38)

Orthologs

Mouse Adra2a: ENSMUSG00000033717

UniProt

P08913

neXtProt

NX_P08913

Human splice variants
Mouse splice variants

Protein structure