ADAMTS9

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 9

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum, Vesicles

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Cancer-related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

3 (64515654 - 64688000)

Ensembl ID

ENSG00000163638  (ver. 103.38)

Orthologs

Mouse Adamts9: ENSMUSG00000030022

UniProt

Q9P2N4

neXtProt

NX_Q9P2N4

Human splice variants
Mouse splice variants

Protein structure