UBA3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Ubiquitin like modifier activating enzyme 3

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm, Plasma membrane, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (69054730 - 69080408)

Ensembl ID

ENSG00000144744  (ver. 103.38)

Orthologs

Mouse Uba3: ENSMUSG00000030061

UniProt

Q8TBC4

neXtProt

NX_Q8TBC4

Human splice variants
Mouse splice variants

Protein structure