16178-1-AP

antibody from Proteintech Group

Targeting: LIN28B CSDD2, FLJ16517

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

16178-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#16178-1-AP, RRID:AB_2135051

Product name

Lin28B-specific antibody

Antibody type

Polyclonal

Description

KD/KO validated Lin28B-specific antibody (Cat. #16178-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Long Non-Coding RNA LINC00467 Correlates to Poor Prognosis and Aggressiveness of Breast Cancer.

Zhang Y, Sun Y, Ding L, Shi W, Ding K, Zhu Y
Frontiers in oncology 2021;11:643394

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Lin 28A/Occludin axis: An aberrantly activated pathway in intestinal epithelial cells leading to impaired barrier function under total parenteral nutrition.

Liu Y, Gong Z, Zhou J, Yan J, Cai W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21189

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LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability.

Keskin T, Bakaric A, Waszyk P, Boulay G, Torsello M, Cornaz-Buros S, Chevalier N, Geiser T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen PG, Carcaboso AM, Mora J, Renella R, Suvà ML, Fusco C, Provero P, Rivera MN, Riggi N, Stamenkovic I
Cell reports 2020 Mar 31;30(13):4567-4583.e5

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LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma.

Keskin T, Bakaric A, Waszyk P, Boulay G, Torsello M, Cornaz-Buros S, Chevalier N, Geiser T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen PG, Carcaboso AM, Mora J, Renella R, Suvà ML, Fusco C, Provero P, Rivera MN, Riggi N, Stamenkovic I
Cell reports 2020 Apr 14;31(2):107539

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Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.

Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115

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Exosomes Serve as Nanoparticles to Deliver Anti-miR-214 to Reverse Chemoresistance to Cisplatin in Gastric Cancer.

Wang X, Zhang H, Bai M, Ning T, Ge S, Deng T, Liu R, Zhang L, Ying G, Ba Y
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Mar 7;26(3):774-783

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Different expression patterns of Lin28 and Lin28b in mouse molar development.

Dong N, Liu Y, Zhang T, Zhao L, Tian J, Ruan J
Archives of oral biology 2017 Oct;82:280-285

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Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.

Wu TF, Li YC, Ma SR, Bing-Liu, Zhang WF, Sun ZJ
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Apr;39(4):1010428317695930

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Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer.

Albino D, Civenni G, Dallavalle C, Roos M, Jahns H, Curti L, Rossi S, Pinton S, D'Ambrosio G, Sessa F, Hall J, Catapano CV, Carbone GM
Cancer research 2016 Jun 15;76(12):3629-43

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JMJD1A promotes tumorigenesis and forms a feedback loop with EZH2/let-7c in NSCLC cells.

Zhan M, Wen F, Liu L, Chen Z, Wei H, Zhou H
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):11237-47

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Testicular expression of the Lin28/let-7 system: Hormonal regulation and changes during postnatal maturation and after manipulations of puberty.

Sangiao-Alvarellos S, Manfredi-Lozano M, Ruiz-Pino F, León S, Morales C, Cordido F, Gaytán F, Pinilla L, Tena-Sempere M
Scientific reports 2015 Oct 23;5:15683

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Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.

Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, Kang YJ, Yoshida H, Koike K
PloS one 2013;8(9):e71969

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Increased expression of Lin28B associates with poor prognosis in patients with oral squamous cell carcinoma.

Wu T, Jia J, Xiong X, He H, Bu L, Zhao Z, Huang C, Zhang W
PloS one 2013;8(12):e83869

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Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism.

Gaytan F, Sangiao-Alvarellos S, Manfredi-Lozano M, García-Galiano D, Ruiz-Pino F, Romero-Ruiz A, León S, Morales C, Cordido F, Pinilla L, Tena-Sempere M
Endocrinology 2013 Mar;154(3):1321-36

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Lin28B-specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Lin28B-specific. This antibody recognizes human, mouse antigen. The Lin28B-specific antibody has been validated for the following applications: ELISA, IHC, IF analysis.

Appendix

16178-1-AP.pdf

Show more

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human testis using 16178-1-AP(Lin28B-specific antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human testis using 16178-1-AP(Lin28B-specific antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue