CABT-BL2148

LIN28B antibody from Creative Diagnostics
CSDD2, FLJ16517
Western blot
Recommended by provider
ELISA
Recommended by provider
Immunohistochemistry
Recommended by provider

Antibody data

Product number
CABT-BL2148
Provider
Creative Diagnostics
Product name
Anti-LIN28B polyclonal antibody
Provider product page
Creative Diagnostics - CABT-BL2148
Antibody type
Polyclonal
Description
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5-GGAG-3 motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5-GGAG-3 motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.