EDN2

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Description

Endothelin 2

Tissue specificity

Tissue enhanced (esophagus, intestine, vagina)

Subcell location

Cytosol

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (41478775 - 41484683)

Ensembl ID

ENSG00000127129  (ver. 103.38)

Orthologs

Mouse Edn2: ENSMUSG00000028635

UniProt

P20800

neXtProt

NX_P20800

Human splice variants
Mouse splice variants

Protein structure