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Protein structure
MAN1B1
Mannosidase alpha class 1B member 1ERManI, MANA-ER, MRT15
This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
Top validated antibodies |
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| Novus Biologicals |  NBP2-13167 |
3 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN4309460 |
Monoclonal |
WB
EL
ICC
IP
IHC
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| GeneTex | GTX105882 |
1 references | Polyclonal |
WB
IHC
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| Abnova Corporation | H00011253-M01 |
Monoclonal |
WB
EL
IHC
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| Biorbyt | orb955301 |
Polyclonal |
WB
EL
ICC
IHC
|
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