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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Flow cytometry [1]
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- Product number
- 12-0969-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD96 (TACTILE) Monoclonal Antibody (NK92.39), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The NK92.39.1 monoclonal antibody reacts with human CD96 also known as TACTILE (T cells-activated increased late expression). CD96 is a type I membrane protein of the Immunoglobulin Superfamily. CD96 promotes NK cell adhesion to cells expressing the polio virus receptor (CD155). Therefore CD96 is an additional receptor for CD155. After binding of PVR to CD96, the PVR can be transferred to the target cell and CD96 can be internalized with bound PVR. This internalization may lead to cell death of the NK cell. This phenomenon may be significant in tumor cells which express high levels of PVR. Furthermore expression of CD96 has been found in the majority of CD34(+)CD38(-) Acute Myeloid Leukemic cells.
- Conjugate
- Yellow dye
- Antibody clone number
- NK92.39
- Concentration
- 5 µL/Test
Submitted references Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell leukemia and lymphoma.
Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.
Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism.
Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection.
CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.
Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).
Oelsner S, Friede ME, Zhang C, Wagner J, Badura S, Bader P, Ullrich E, Ottmann OG, Klingemann H, Tonn T, Wels WS
Cytotherapy 2017 Feb;19(2):235-249
Cytotherapy 2017 Feb;19(2):235-249
Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.
Ho TC, LaMere M, Stevens BM, Ashton JM, Myers JR, O'Dwyer KM, Liesveld JL, Mendler JH, Guzman M, Morrissette JD, Zhao J, Wang ES, Wetzler M, Jordan CT, Becker MW
Blood 2016 Sep 29;128(13):1671-8
Blood 2016 Sep 29;128(13):1671-8
Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism.
Gruenbacher G, Nussbaumer O, Gander H, Steiner B, Leonhartsberger N, Thurnher M
Oncoimmunology 2014;3(8):e953410
Oncoimmunology 2014;3(8):e953410
Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection.
Eriksson EM, Keh CE, Deeks SG, Martin JN, Hecht FM, Nixon DF
PloS one 2012;7(12):e51696
PloS one 2012;7(12):e51696
CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.
Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, Krensky AM, Weissman IL
Proceedings of the National Academy of Sciences of the United States of America 2007 Jun 26;104(26):11008-13
Proceedings of the National Academy of Sciences of the United States of America 2007 Jun 26;104(26):11008-13
Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).
Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M
Journal of immunology (Baltimore, Md. : 1950) 2004 Apr 1;172(7):3994-8
Journal of immunology (Baltimore, Md. : 1950) 2004 Apr 1;172(7):3994-8
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD19 FITC (Product # 11-0199-42) and Mouse IgG1 kappa Isotype Control PE (Product # 12-4714-81) (left) or Anti-Human CD96 (TACTILE) PE (right). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Yellow dye
