BS8084

antibody from Bioworld Technology, Inc
Targeting: GLRX3 bA500G10.4, GLRX4, GRX3, GRX4, PICOT, TXNL2
Provider product page for BS8084
Western blot
Immunohistochemistry

Antibody data

Product number
BS8084 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GLRX3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GLRX3.
Description
PICOT, also known as GLRX3 (glutaredoxin 3), GRX3, GRX4, GLRX4, HUSSY-22, TXNL2 or TXNL3, is a 335 amino acid protein that contains one thioredoxin domain and two glutaredoxin domains. Localized to the cytoplasm and the cell cortex, PICOT is thought to play a role in regulating the thioredoxin system and may weakly interact with PKC IJ (protein kinase C theta). Through its ability to regulate the thioredoxin pathway, PICOT inhibits cardiac hypertrophy (a thickening of the heart muscle usually caused by high blood pressure) by negatively regulating NFAT (Nuclear factor of activated T-cells) signaling. Although PICOT contains one thioredoxin domain, it lacks the two redox-reactive cysteines that are required for catalytic activity, suggesting that PICOT lacks thioredoxin function. PICOT is expressed in testis, heart and spleen with lower levels detected in thymus, lung, colon, placenta and small intestine.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GLRX3 protein structure - BS8084 shown in red.