RBFOX3

This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

Description

RNA binding fox-1 homolog 3

Tissue specificity

Tissue enhanced (brain, intestine, urinary bladder)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

17 (79089345 - 79516148)

Ensembl ID

ENSG00000167281  (ver. 103.38)

Orthologs

Mouse Rbfox3: ENSMUSG00000025576

UniProt

A6NFN3

neXtProt

NX_A6NFN3

Human splice variants
Mouse splice variants

Protein structure