SERPIND1

This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]

Description

Serpin family D member 1

Tissue specificity

Tissue enriched (liver)

Subcell location

Vesicles

Predicted location

Secreted to blood

Protein family

Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (20774113 - 20787720)

Ensembl ID

ENSG00000099937  (ver. 103.38)

Orthologs

Mouse Serpind1: ENSMUSG00000022766

UniProt

P05546

neXtProt

NX_P05546

Human splice variants
Mouse splice variants

Protein structure