LIPT1

The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]

Description

Lipoyltransferase 1

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

2 (99154955 - 99163157)

Ensembl ID

ENSG00000144182  (ver. 103.38)

Orthologs

Mouse Lipt1: ENSMUSG00000037216

UniProt

Q9Y234

neXtProt

NX_Q9Y234

Human splice variants
Mouse splice variants

Protein structure