ENPP3

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

Description

Ectonucleotide pyrophosphatase/phosphodiesterase 3

Tissue specificity

Tissue enhanced (cervix, intestine)

Predicted location

Intracellular, Secreted - unknown location

Protein family

CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (131628442 - 131747418)

Ensembl ID

ENSG00000154269  (ver. 103.38)

Orthologs

Mouse Enpp3: ENSMUSG00000019989

UniProt

O14638

neXtProt

NX_O14638

Human splice variants
Mouse splice variants

Protein structure