PTPRH

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Description

Protein tyrosine phosphatase receptor type H

Tissue specificity

Tissue enhanced (gallbladder, intestine, stomach)

Subcell location

Mitochondria

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins

Chromosome

19 (55181247 - 55209506)

Ensembl ID

ENSG00000080031  (ver. 103.38)

Orthologs

Mouse Ptprh: ENSMUSG00000035429

UniProt

Q9HD43

neXtProt

NX_Q9HD43

Human splice variants
Mouse splice variants

Protein structure