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Protein structure
INSIG1
Insulin induced gene 1CL-6, MGC1405
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Top validated antibodies |
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| Proteintech Group |  22115-1-AP |
6 references | Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN2036077 |
Polyclonal |
WB
EL
IHC
FC
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| Novus Biologicals | NB110-55244 |
4 references | Polyclonal |
WB
ICC
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| Aviva Systems Biology | OAAB05536 |
Polyclonal |
WB
EL
IHC
FC
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| Invitrogen Antibodies | PA5-97876 |
Polyclonal |
WB
EL
ICC
IHC
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