DDX18

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

Description

DEAD-box helicase 18

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Nucleoli rim, Mitotic chromosome

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (117814691 - 117832377)

Ensembl ID

ENSG00000088205  (ver. 103.38)

Orthologs

Mouse Ddx18: ENSMUSG00000001674

UniProt

Q9NVP1

neXtProt

NX_Q9NVP1

Human splice variants
Mouse splice variants

Protein structure