EN1

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

Description

Engrailed homeobox 1

Tissue specificity

Group enriched (brain, skeletal muscle, skin)

Subcell location

Nucleoplasm, Nucleoli rim

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

2 (118842171 - 118847648)

Ensembl ID

ENSG00000163064  (ver. 103.38)

Orthologs

Mouse En1: ENSMUSG00000058665

UniProt

Q05925

neXtProt

NX_Q05925

Human splice variants
Mouse splice variants

Protein structure