RYK

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Description

Receptor like tyrosine kinase

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus, Cytosol

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (134065303 - 134250859)

Ensembl ID

ENSG00000163785  (ver. 103.38)

Orthologs

Mouse Ryk: ENSMUSG00000032547

UniProt

P34925

neXtProt

NX_P34925

Human splice variants
Mouse splice variants

Protein structure