DBR1

The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]

Description

Debranching RNA lariats 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (138160988 - 138174921)

Ensembl ID

ENSG00000138231  (ver. 103.38)

Orthologs

Mouse Dbr1: ENSMUSG00000032469

UniProt

Q9UK59

neXtProt

NX_Q9UK59

Human splice variants
Mouse splice variants

Protein structure