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Protein structure
PTPN18
Protein tyrosine phosphatase non-receptor type 18BDP1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Top validated antibodies |
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| Proteintech Group |  17551-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| Biorbyt | orb317982 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | H00026469-B01P |
1 references | Polyclonal |
WB
ICC
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| antibodies-online | ABIN525721 |
1 references | Polyclonal |
WB
ICC
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| NovoPro Bioscience Inc. | 114317 |
Polyclonal |
WB
EL
IHC
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