ABIN252476

antibody from antibodies-online

Targeting: TNFSF11 CD254, ODF, OPGL, RANKL, TRANCE

Provider product page for ABIN252476

Western blot

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Chromatin Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [20]
Comments [0]
Validations
Western blot [4]
Immunohistochemistry [3]

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Product number: ABIN252476 - Provider product page
Provider: antibodies-online
Product name: anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody
Antibody type: Monoclonal
Description: Protein G purified
Reactivity: Human, Mouse, Rat
Host: Mouse
Epitope: AA 1-317
Isotype: IgG
Antibody clone number: 12A668
Vial size: 0.1 mg
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Handling: Avoid freeze-thaw cycles

TNFSF11 protein structure - ABIN252476 shown in red.

Submitted references HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression.

Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L
In vitro cellular & developmental biology. Animal 2015 Sep;51(8):808-14

Increased calcification in osteoprotegerin-deficient smooth muscle cells: Dependence on receptor activator of NF-κB ligand and interleukin 6.

Callegari A, Coons ML, Ricks JL, Rosenfeld ME, Scatena M
Journal of vascular research 2014;51(2):118-31

Involvement of ERK and p38 MAPK pathways on Interleukin-33-induced RANKL expression in osteoblastic cells.

Mine Y, Makihira S, Yamaguchi Y, Tanaka H, Nikawa H
Cell biology international 2014 May;38(5):655-62

The effect of dose on rhBMP-2 signaling, delivered via collagen sponge, on osteoclast activation and in vivo bone resorption.

Kim RY, Oh JH, Lee BS, Seo YK, Hwang SJ, Kim IS
Biomaterials 2014 Feb;35(6):1869-81

Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: an interracial comparative study.

Hu P, Chung LW, Berel D, Frierson HF, Yang H, Liu C, Wang R, Li Q, Rogatko A, Zhau HE
PloS one 2013;8(9):e73081

Lesional infiltration of receptor activator of nuclear factor-κB ligand⁺ cells in experimental autoimmune neuritis rats.

Yin Y, Schluesener HJ, Zhang ZY, Zhang Z
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013 Jun;34(6):905-9

T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet A1 challenge.

Gambichler T, Terras S, Kampilafkos P, Kreuter A, Skrygan M
The British journal of dermatology 2013 Dec;169(6):1288-94

Denosumab treatment for fibrous dysplasia.

Boyce AM, Chong WH, Yao J, Gafni RI, Kelly MH, Chamberlain CE, Bassim C, Cherman N, Ellsworth M, Kasa-Vubu JZ, Farley FA, Molinolo AA, Bhattacharyya N, Collins MT
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Jul;27(7):1462-70

Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer.

Hu P, Chu GC, Zhu G, Yang H, Luthringer D, Prins G, Habib F, Wang Y, Wang R, Chung LW, Zhau HE
PloS one 2011;6(12):e28670

The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells.

Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E
Carcinogenesis 2011 Nov;32(11):1634-40

Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia.

Parrula C, Zimmerman B, Nadella P, Shu S, Rosol T, Fernandez S, Lairmore M, Niewiesk S
Veterinary pathology 2009 Sep;46(5):1003-14

Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol.

Ghoreishi M, Bach P, Obst J, Komba M, Fleet JC, Dutz JP
Journal of immunology (Baltimore, Md. : 1950) 2009 May 15;182(10):6071-8

Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis.

Neidhart M, Baraliakos X, Seemayer C, Zelder C, Gay RE, Michel BA, Boehm H, Gay S, Braun J
Annals of the rheumatic diseases 2009 Aug;68(8):1334-9

Ameloblastoma induces osteoclastogenesis: a possible role of ameloblastoma in expanding in the bone.

Sandra F, Hendarmin L, Kukita T, Nakao Y, Nakamura N, Nakamura S
Oral oncology 2005 Jul;41(6):637-44

Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis.

Rubin J, Chung LW, Fan X, Zhu L, Murphy TC, Nanes MS, Rosen CJ
The Prostate 2004 Jan 1;58(1):41-9

Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.

Niida S, Kawahara M, Ishizuka Y, Ikeda Y, Kondo T, Hibi T, Suzuki Y, Ikeda K, Taniguchi N
The Journal of biological chemistry 2004 Feb 13;279(7):5752-6

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression.

Pearse RN, Sordillo EM, Yaccoby S, Wong BR, Liau DF, Colman N, Michaeli J, Epstein J, Choi Y
Proceedings of the National Academy of Sciences of the United States of America 2001 Sep 25;98(20):11581-6

Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.

Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillenwater AM, Cabanillas F, Aggarwal BB, Younes A
Blood 2001 Nov 1;98(9):2784-90

Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.

Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):3574-9

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.

Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 30;96(7):3540-5

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