RAMP1

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Description

Receptor activity modifying protein 1

Tissue specificity

Tissue enhanced (endometrium)

Subcell location

Nucleoplasm, Nuclear membrane

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2 (237858893 - 237912106)

Ensembl ID

ENSG00000132329  (ver. 103.38)

Orthologs

Mouse Ramp1: ENSMUSG00000034353

UniProt

O60894

neXtProt

NX_O60894

Human splice variants
Mouse splice variants

Protein structure