BMP6

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]

Description

Bone morphogenetic protein 6

Tissue specificity

Tissue enhanced (placenta)

Subcell location

Mitochondria

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

6 (7726099 - 7881728)

Ensembl ID

ENSG00000153162  (ver. 103.38)

Orthologs

Mouse Bmp6: ENSMUSG00000039004

UniProt

P22004

neXtProt

NX_P22004

Human splice variants
Mouse splice variants

Protein structure