CDC42BPA

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

Description

CDC42 binding protein kinase alpha

Tissue specificity

Low tissue specificity

Subcell location

Intermediate filaments

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (226989865 - 227318474)

Ensembl ID

ENSG00000143776  (ver. 103.38)

Orthologs

Mouse Cdc42bpa: ENSMUSG00000026490

UniProt

Q5VT25

neXtProt

NX_Q5VT25

Human splice variants
Mouse splice variants

Protein structure