TP73

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Description

Tumor protein p73

Tissue specificity

Tissue enhanced (choroid plexus, fallopian tube, skin)

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

1 (3652516 - 3736201)

Ensembl ID

ENSG00000078900  (ver. 103.38)

Orthologs

Mouse Trp73: ENSMUSG00000029026

UniProt

O15350

neXtProt

NX_O15350

Human splice variants
Mouse splice variants

Protein structure