HYAL3

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Description

Hyaluronidase 3

Tissue specificity

Tissue enhanced (bone marrow)

Predicted location

Intracellular, Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

3 (50292831 - 50299405)

Ensembl ID

ENSG00000186792  (ver. 103.38)

Orthologs

Mouse Hyal3: ENSMUSG00000036091

UniProt

O43820

neXtProt

NX_O43820

Human splice variants
Mouse splice variants

Protein structure