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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [109]
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- Validations
- Western blot [2]
- Immunocytochemistry [2]
- Flow cytometry [1]
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- Product number
- MAB2018 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse/Rat SOX2 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human, mouse, and rat SOX2 in Western blots.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
P48431- Isotype
- IgG
- Antibody clone number
- 245610
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer.
Generation of an induced pluripotent stem cell line (TRNDi008-A) from a Hunter syndrome patient carrying a hemizygous 208insC mutation in the IDS gene.
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation.
Generation of an induced pluripotent stem cell line (TRNDi004-I) from a Niemann-Pick disease type B patient carrying a heterozygous mutation of p.L43_A44delLA in the SMPD1 gene.
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation.
An induced pluripotent stem cell line (TRNDi006-A) from a MPS IIIB patient carrying homozygous mutation of p.Glu153Lys in the NAGLU gene.
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.
Generation of two induced pluripotent stem cell lines from skin fibroblasts of sisters carrying a c.1094C>A variation in the SCN10A gene potentially associated with small fiber neuropathy.
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.
SOX2 and SOX9 are markers of clinically aggressive disease in metastatic high-grade serous carcinoma.
An induced pluripotent stem cell line (TRNDi009-C) from a Niemann-Pick disease type A patient carrying a heterozygous p.L302P (c.905 T>C) mutation in the SMPD1 gene.
The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line.
Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p.Q510P mutation in the PTPN11 gene.
Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p.Q208X and p.G310G mutations in the NGLY1 gene.
Single-cell transcriptomic analysis of mouse neocortical development.
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene.
Generation of an induced pluripotent stem cell line (TRNDi005-A) from a Mucopolysaccharidosis Type IVA (MPS IVA) patient carrying compound heterozygous p.R61W and p.WT405del mutations in the GALNS gene.
User-defined morphogen patterning for directing human cell fate stratification.
Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.
Differential Response in Novel Stem Cell Niches of the Brain after Cervical Spinal Cord Injury and Traumatic Brain Injury.
Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells.
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi003-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1.
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene.
TFAP2C regulates transcription in human naive pluripotency by opening enhancers.
Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas.
INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.
FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury.
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
Generation of two induced pluripotent stem cells lines from a Mucopolysaccharydosis IIIB (MPSIIIB) patient.
Generation of the human induced pluripotent stem cell line (UKWNLi001-A) from skin fibroblasts of a woman with Fabry disease carrying the X-chromosomal heterozygous c.708 G > C (W236C) missense mutation in exon 5 of the alpha-galactosidase-A gene.
Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel.
Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata).
The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo.
Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein.
Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer.
Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells.
Laminin α5 substrates promote survival, network formation and functional development of human pluripotent stem cell-derived neurons in vitro.
Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson's disease, as an anti-cancer stem cell drug.
Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.
Nicotinamide metabolism regulates glioblastoma stem cell maintenance.
A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.
Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo.
A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity.
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA.
Spatial development of gingival fibroblasts and dental pulp cells: Effect of extracellular matrix.
Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9.
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.
Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma.
Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding.
FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1.
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression.
HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia.
Enhancing the Three-Dimensional Structure of Adherent Gingival Fibroblasts and Spheroids via a Fibrous Protein-Based Hydrogel Cover.
Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype.
Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9.
Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9.
SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.
Non integrative strategy decreases chromosome instability and improves endogenous pluripotency genes reactivation in porcine induced pluripotent-like stem cells.
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.
Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.
Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion.
Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation.
EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones.
Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.
A single-cell and feeder-free culture system for monkey embryonic stem cells.
Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex.
Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy.
Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.
The subventricular zone is able to respond to a demyelinating lesion after localized radiation.
Chondroitin sulfate is indispensable for pluripotency and differentiation of mouse embryonic stem cells.
Zrf1 is required to establish and maintain neural progenitor identity.
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.
Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape.
Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb.
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
Embryonic stem cell-based modeling of tau pathology in human neurons.
Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus.
Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium.
REST regulates oncogenic properties of glioblastoma stem cells.
Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells.
Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects.
Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells.
Human haploid cells differentiated from meiotic competent clonal germ cell lines that originated from embryonic stem cells.
Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel.
Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primary mediastinal germ cell tumors.
Noninvasive imaging of endogenous neural stem cell mobilization in vivo using positron emission tomography.
Paternal recognition of adult offspring mediated by newly generated CNS neurons.
Epigenetic changes to human umbilical cord blood cells cultured with three proteins indicate partial reprogramming to a pluripotent state.
Efficient serum-free derivation of oligodendrocyte precursors from neural stem cell-enriched cultures.
Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells.
The intracellular distribution of the ES cell totipotent markers OCT4 and Sox2 in adult stem cells differs dramatically according to commercial antibody used.
Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria.
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.
Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue.
Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.
Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1.
Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy.
Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats.
Melissaridou S, Wiechec E, Magan M, Jain MV, Chung MK, Farnebo L, Roberg K
Cancer cell international 2019;19:16
Cancer cell international 2019;19:16
Generation of an induced pluripotent stem cell line (TRNDi008-A) from a Hunter syndrome patient carrying a hemizygous 208insC mutation in the IDS gene.
Hong J, Xu M, Li R, Cheng YS, Kouznetsova J, Beers J, Liu C, Zou J, Zheng W
Stem cell research 2019 May;37:101451
Stem cell research 2019 May;37:101451
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation.
Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabrò F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M
Stem cell research 2019 May;37:101437
Stem cell research 2019 May;37:101437
Generation of an induced pluripotent stem cell line (TRNDi004-I) from a Niemann-Pick disease type B patient carrying a heterozygous mutation of p.L43_A44delLA in the SMPD1 gene.
Baskfield A, Li R, Beers J, Zou J, Liu C, Zheng W
Stem cell research 2019 May;37:101436
Stem cell research 2019 May;37:101436
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation.
Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabrò F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M
Stem cell research 2019 May;37:101431
Stem cell research 2019 May;37:101431
An induced pluripotent stem cell line (TRNDi006-A) from a MPS IIIB patient carrying homozygous mutation of p.Glu153Lys in the NAGLU gene.
Huang W, Xu M, Li R, Baskfield A, Kouznetsova J, Beers J, Zou J, Liu C, Zheng W
Stem cell research 2019 May;37:101427
Stem cell research 2019 May;37:101427
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Calatayud C, Carola G, Fernández-Carasa I, Valtorta M, Jiménez-Delgado S, Díaz M, Soriano-Fradera J, Cappelletti G, García-Sancho J, Raya Á, Consiglio A
Scientific reports 2019 May 2;9(1):6811
Scientific reports 2019 May 2;9(1):6811
Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.
Zurkirchen L, Varum S, Giger S, Klug A, Häusel J, Bossart R, Zemke M, Cantù C, Atak ZK, Zamboni N, Basler K, Sommer L
Nature communications 2019 May 16;10(1):2192
Nature communications 2019 May 16;10(1):2192
Generation of two induced pluripotent stem cell lines from skin fibroblasts of sisters carrying a c.1094C>A variation in the SCN10A gene potentially associated with small fiber neuropathy.
Klein T, Klug K, Henkel L, Kwok CK, Edenhofer F, Klopocki E, Kurth I, Üçeyler N
Stem cell research 2019 Mar;35:101396
Stem cell research 2019 Mar;35:101396
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.
Kim H, Park HJ, Choi H, Chang Y, Park H, Shin J, Kim J, Lengner CJ, Lee YK, Kim J
Stem cell reports 2019 Mar 5;12(3):518-531
Stem cell reports 2019 Mar 5;12(3):518-531
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoué K, Offenhäuser C, Akgül S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW
Scientific reports 2019 Mar 20;9(1):4902
Scientific reports 2019 Mar 20;9(1):4902
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.
Ajmone-Cat MA, Onori A, Toselli C, Stronati E, Morlando M, Bozzoni I, Monni E, Kokaia Z, Lupo G, Minghetti L, Biagioni S, Cacci E
Scientific reports 2019 Mar 14;9(1):4572
Scientific reports 2019 Mar 14;9(1):4572
SOX2 and SOX9 are markers of clinically aggressive disease in metastatic high-grade serous carcinoma.
Sherman-Samis M, Onallah H, Holth A, Reich R, Davidson B
Gynecologic oncology 2019 Jun;153(3):651-660
Gynecologic oncology 2019 Jun;153(3):651-660
An induced pluripotent stem cell line (TRNDi009-C) from a Niemann-Pick disease type A patient carrying a heterozygous p.L302P (c.905 T>C) mutation in the SMPD1 gene.
Baskfield A, Li R, Beers J, Zou J, Liu C, Zheng W
Stem cell research 2019 Jul;38:101461
Stem cell research 2019 Jul;38:101461
The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line.
Howden S, Hosseini Far H, Motazedian A, Elefanty AG, Stanley EG, Lamandé SR, Bateman JF
Stem cell research 2019 Jul;38:101453
Stem cell research 2019 Jul;38:101453
Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p.Q510P mutation in the PTPN11 gene.
Li R, Baskfield A, Lin Y, Beers J, Zou J, Liu C, Jaffré F, Roberts AE, Ottinger EA, Kontaridis MI, Zheng W
Stem cell research 2019 Jan;34:101374
Stem cell research 2019 Jan;34:101374
Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p.Q208X and p.G310G mutations in the NGLY1 gene.
Li R, Pradhan M, Xu M, Baskfield A, Farkhondeh A, Cheng YS, Beers J, Zou J, Liu C, Might M, Rodems S, Zheng W
Stem cell research 2019 Jan;34:101362
Stem cell research 2019 Jan;34:101362
Single-cell transcriptomic analysis of mouse neocortical development.
Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ
Nature communications 2019 Jan 11;10(1):134
Nature communications 2019 Jan 11;10(1):134
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene.
Mura M, Pisano F, Stefanello M, Ginevrino M, Boni M, Calabrò F, Crotti L, Valente EM, Schwartz PJ, Brink PA, Gnecchi M
Stem cell research 2019 Apr;36:101416
Stem cell research 2019 Apr;36:101416
Generation of an induced pluripotent stem cell line (TRNDi005-A) from a Mucopolysaccharidosis Type IVA (MPS IVA) patient carrying compound heterozygous p.R61W and p.WT405del mutations in the GALNS gene.
Li R, Baskfield A, Beers J, Zou J, Liu C, Alméciga-Díaz CJ, Zheng W
Stem cell research 2019 Apr;36:101408
Stem cell research 2019 Apr;36:101408
User-defined morphogen patterning for directing human cell fate stratification.
Regier MC, Tokar JJ, Warrick JW, Pabon L, Berthier E, Beebe DJ, Stevens KR
Scientific reports 2019 Apr 23;9(1):6433
Scientific reports 2019 Apr 23;9(1):6433
Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.
Chen M, Laursen SH, Habekost M, Knudsen CH, Buchholdt SH, Huang J, Xu F, Liu X, Bolund L, Luo Y, Nissen P, Febbraro F, Denham M
Frontiers in cell and developmental biology 2018;6:5
Frontiers in cell and developmental biology 2018;6:5
Differential Response in Novel Stem Cell Niches of the Brain after Cervical Spinal Cord Injury and Traumatic Brain Injury.
Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC
Journal of neurotrauma 2018 Sep 15;35(18):2195-2207
Journal of neurotrauma 2018 Sep 15;35(18):2195-2207
Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells.
Jeong M, O'Reilly M, Kirkwood NK, Al-Aama J, Lako M, Kros CJ, Armstrong L
Cell death & disease 2018 Sep 11;9(9):922
Cell death & disease 2018 Sep 11;9(9):922
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi003-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1.
Mura M, Ginevrino M, Zappatore R, Pisano F, Boni M, Castelletti S, Crotti L, Valente EM, Schwartz PJ, Gnecchi M
Stem cell research 2018 May;29:170-173
Stem cell research 2018 May;29:170-173
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene.
Mura M, Lee YK, Ginevrino M, Zappatore R, Pisano F, Boni M, Dagradi F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M
Stem cell research 2018 May;29:157-161
Stem cell research 2018 May;29:157-161
TFAP2C regulates transcription in human naive pluripotency by opening enhancers.
Pastor WA, Liu W, Chen D, Ho J, Kim R, Hunt TJ, Lukianchikov A, Liu X, Polo JM, Jacobsen SE, Clark AT
Nature cell biology 2018 May;20(5):553-564
Nature cell biology 2018 May;20(5):553-564
Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas.
Aaberg-Jessen C, Sørensen MD, Matos ALSA, Moreira JM, Brünner N, Knudsen A, Kristensen BW
BMC cancer 2018 Mar 9;18(1):270
BMC cancer 2018 Mar 9;18(1):270
INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
Le O, Palacio L, Bernier G, Batinic-Haberle I, Hickson G, Beauséjour C
Stem cell reports 2018 Jun 5;10(6):1721-1733
Stem cell reports 2018 Jun 5;10(6):1721-1733
Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.
Kwak S, Kim TW, Kang BH, Kim JH, Lee JS, Lee HT, Hwang IY, Shin J, Lee JH, Cho EJ, Youn HD
Nucleic acids research 2018 Jul 27;46(13):6592-6607
Nucleic acids research 2018 Jul 27;46(13):6592-6607
FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury.
Alastrue-Agudo A, Rodriguez-Jimenez FJ, Mocholi EL, De Giorgio F, Erceg S, Moreno-Manzano V
International journal of molecular sciences 2018 Jan 9;19(1)
International journal of molecular sciences 2018 Jan 9;19(1)
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.
Yachie-Kinoshita A, Onishi K, Ostblom J, Langley MA, Posfai E, Rossant J, Zandstra PW
Molecular systems biology 2018 Jan 29;14(1):e7952
Molecular systems biology 2018 Jan 29;14(1):e7952
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A
Nature communications 2018 Jan 23;9(1):335
Nature communications 2018 Jan 23;9(1):335
Generation of two induced pluripotent stem cells lines from a Mucopolysaccharydosis IIIB (MPSIIIB) patient.
Vallejo-Diez S, Fleischer A, Martín-Fernández JM, Sánchez-Gilabert A, Bachiller D
Stem cell research 2018 Dec;33:180-184
Stem cell research 2018 Dec;33:180-184
Generation of the human induced pluripotent stem cell line (UKWNLi001-A) from skin fibroblasts of a woman with Fabry disease carrying the X-chromosomal heterozygous c.708 G > C (W236C) missense mutation in exon 5 of the alpha-galactosidase-A gene.
Klein T, Günther K, Kwok CK, Edenhofer F, Üçeyler N
Stem cell research 2018 Aug;31:222-226
Stem cell research 2018 Aug;31:222-226
Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel.
Gao X, Yourick JJ, Sprando RL
Stem cell research 2018 Aug;31:193-196
Stem cell research 2018 Aug;31:193-196
Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata).
Nakai R, Ohnuki M, Kuroki K, Ito H, Hirai H, Kitajima R, Fujimoto T, Nakagawa M, Enard W, Imamura M
Scientific reports 2018 Aug 15;8(1):12187
Scientific reports 2018 Aug 15;8(1):12187
The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo.
Vay SU, Flitsch LJ, Rabenstein M, Rogall R, Blaschke S, Kleinhaus J, Reinert N, Bach A, Fink GR, Schroeter M, Rueger MA
Journal of neuroinflammation 2018 Aug 13;15(1):226
Journal of neuroinflammation 2018 Aug 13;15(1):226
Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein.
Vőfély G, Berecz T, Szabó E, Szebényi K, Hathy E, Orbán TI, Sarkadi B, Homolya L, Marchetto MC, Réthelyi JM, Apáti Á
Molecular and cellular neurosciences 2018 Apr;88:222-230
Molecular and cellular neurosciences 2018 Apr;88:222-230
Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.
Corsini NS, Peer AM, Moeseneder P, Roiuk M, Burkard TR, Theussl HC, Moll I, Knoblich JA
Cell stem cell 2018 Apr 5;22(4):543-558.e12
Cell stem cell 2018 Apr 5;22(4):543-558.e12
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK
Nature communications 2018 Apr 16;9(1):1479
Nature communications 2018 Apr 16;9(1):1479
Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer.
Wang P, Wan WW, Xiong SL, Feng H, Wu N
Cell death discovery 2017;3:16105
Cell death discovery 2017;3:16105
Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells.
Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, Araki T, Kato Y, Shirakawa T, Suzuki Y, Yamauchi J, Yoshida S, Sato N
PloS one 2017;12(2):e0171947
PloS one 2017;12(2):e0171947
Laminin α5 substrates promote survival, network formation and functional development of human pluripotent stem cell-derived neurons in vitro.
Hyysalo A, Ristola M, Mäkinen ME, Häyrynen S, Nykter M, Narkilahti S
Stem cell research 2017 Oct;24:118-127
Stem cell research 2017 Oct;24:118-127
Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson's disease, as an anti-cancer stem cell drug.
Okada M, Takeda H, Sakaki H, Kuramoto K, Suzuki S, Sanomachi T, Togashi K, Seino S, Kitanaka C
Oncotarget 2017 Nov 7;8(55):94872-94882
Oncotarget 2017 Nov 7;8(55):94872-94882
Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.
Sharma TP, Wiley LA, Whitmore SS, Anfinson KR, Cranston CM, Oppedal DJ, Daggett HT, Mullins RF, Tucker BA, Stone EM
Stem cell research 2017 May;21:58-70
Stem cell research 2017 May;21:58-70
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.
Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJY, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, Fang X, Regev A, Suvà ML, Hwang TH, Locasale JW, Bao S, Rich JN
Nature neuroscience 2017 May;20(5):661-673
Nature neuroscience 2017 May;20(5):661-673
Nicotinamide metabolism regulates glioblastoma stem cell maintenance.
Jung J, Kim LJ, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN
JCI insight 2017 May 18;2(10)
JCI insight 2017 May 18;2(10)
A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.
Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo N, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC
Circulation research 2017 May 12;120(10):1561-1571
Circulation research 2017 May 12;120(10):1561-1571
Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo.
Jensen SS, Petterson SA, Halle B, Aaberg-Jessen C, Kristensen BW
BMC cancer 2017 Mar 7;17(1):178
BMC cancer 2017 Mar 7;17(1):178
A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity.
Riddick G, Kotliarova S, Rodriguez V, Kim HS, Linkous A, Storaska AJ, Ahn S, Walling J, Belova G, Fine HA
Scientific reports 2017 Mar 3;7:43605
Scientific reports 2017 Mar 3;7:43605
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA.
Talamillo A, Grande L, Ruiz-Ontañon P, Velasquez C, Mollinedo P, Torices S, Sanchez-Gomez P, Aznar A, Esparis-Ogando A, Lopez-Lopez C, Lafita C, Berciano MT, Montero JA, Vazquez-Barquero A, Segura V, Villagra NT, Pandiella A, Lafarga M, Leon J, Martinez-Climent JA, Sanz-Moreno V, Fernandez-Luna JL
Oncogene 2017 Mar 23;36(12):1733-1744
Oncogene 2017 Mar 23;36(12):1733-1744
Spatial development of gingival fibroblasts and dental pulp cells: Effect of extracellular matrix.
Kaufman G, Skrtic D
Tissue & cell 2017 Jun;49(3):401-409
Tissue & cell 2017 Jun;49(3):401-409
Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9.
Xu Y, Wu Y, Guo D, Gao G, Lai K, Yang F, Wang K, Wu H, Lai L, Li J, Xu K, Li YX
Stem cell research 2017 Jul;22:29-32
Stem cell research 2017 Jul;22:29-32
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.
King HO, Brend T, Payne HL, Wright A, Ward TA, Patel K, Egnuni T, Stead LF, Patel A, Wurdak H, Short SC
Stem cell reports 2017 Jan 10;8(1):125-139
Stem cell reports 2017 Jan 10;8(1):125-139
Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma.
Bayat Mokhtari R, Baluch N, Ka Hon Tsui M, Kumar S, S Homayouni T, Aitken K, Das B, Baruchel S, Yeger H
BMC cancer 2017 Feb 24;17(1):156
BMC cancer 2017 Feb 24;17(1):156
Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding.
Falk S, Bugeon S, Ninkovic J, Pilz GA, Postiglione MP, Cremer H, Knoblich JA, Götz M
Neuron 2017 Feb 22;93(4):777-791.e3
Neuron 2017 Feb 22;93(4):777-791.e3
FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1.
Hirano K, Namihira M
FEBS open bio 2017 Dec;7(12):1932-1942
FEBS open bio 2017 Dec;7(12):1932-1942
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression.
Alvarado AG, Thiagarajan PS, Mulkearns-Hubert EE, Silver DJ, Hale JS, Alban TJ, Turaga SM, Jarrar A, Reizes O, Longworth MS, Vogelbaum MA, Lathia JD
Cell stem cell 2017 Apr 6;20(4):450-461.e4
Cell stem cell 2017 Apr 6;20(4):450-461.e4
HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia.
Wang P, Lan C, Xiong S, Zhao X, Shan Y, Hu R, Wan W, Yu S, Liao B, Li G, Wang J, Zou D, Chen B, Feng H, Wu N
Oncotarget 2017 Apr 25;8(17):28074-28092
Oncotarget 2017 Apr 25;8(17):28074-28092
Enhancing the Three-Dimensional Structure of Adherent Gingival Fibroblasts and Spheroids via a Fibrous Protein-Based Hydrogel Cover.
Kaufman G, Nunes L, Eftimiades A, Tutak W
Cells, tissues, organs 2016;202(5-6):343-354
Cells, tissues, organs 2016;202(5-6):343-354
Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype.
Munthe S, Petterson SA, Dahlrot RH, Poulsen FR, Hansen S, Kristensen BW
PloS one 2016;11(5):e0155106
PloS one 2016;11(5):e0155106
Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9.
Bara AM, Messana A, Herring A, Hazelbaker DZ, Eggan K, Barrett LE
Stem cell research 2016 Sep;17(2):441-443
Stem cell research 2016 Sep;17(2):441-443
Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9.
Herring A, Messana A, Bara AM, Hazelbaker DZ, Eggan K, Barrett LE
Stem cell research 2016 Sep;17(2):430-432
Stem cell research 2016 Sep;17(2):430-432
SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.
Kim BR, Van de Laar E, Cabanero M, Tarumi S, Hasenoeder S, Wang D, Virtanen C, Suzuki T, Bandarchi B, Sakashita S, Pham NA, Lee S, Keshavjee S, Waddell TK, Tsao MS, Moghal N
PLoS biology 2016 Nov;14(11):e1002581
PLoS biology 2016 Nov;14(11):e1002581
Non integrative strategy decreases chromosome instability and improves endogenous pluripotency genes reactivation in porcine induced pluripotent-like stem cells.
Congras A, Barasc H, Canale-Tabet K, Plisson-Petit F, Delcros C, Feraud O, Oudrhiri N, Hadadi E, Griscelli F, Bennaceur-Griscelli A, Turhan A, Afanassieff M, Ferchaud S, Pinton A, Yerle-Bouissou M, Acloque H
Scientific reports 2016 Jun 1;6:27059
Scientific reports 2016 Jun 1;6:27059
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.
Wiley LA, Burnight ER, DeLuca AP, Anfinson KR, Cranston CM, Kaalberg EE, Penticoff JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA
Scientific reports 2016 Jul 29;6:30742
Scientific reports 2016 Jul 29;6:30742
Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.
Long Y, Xu M, Li R, Dai S, Beers J, Chen G, Soheilian F, Baxa U, Wang M, Marugan JJ, Muro S, Li Z, Brady R, Zheng W
Stem cells translational medicine 2016 Dec;5(12):1644-1655
Stem cells translational medicine 2016 Dec;5(12):1644-1655
Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion.
Otvos B, Silver DJ, Mulkearns-Hubert EE, Alvarado AG, Turaga SM, Sorensen MD, Rayman P, Flavahan WA, Hale JS, Stoltz K, Sinyuk M, Wu Q, Jarrar A, Kim SH, Fox PL, Nakano I, Rich JN, Ransohoff RM, Finke J, Kristensen BW, Vogelbaum MA, Lathia JD
Stem cells (Dayton, Ohio) 2016 Aug;34(8):2026-39
Stem cells (Dayton, Ohio) 2016 Aug;34(8):2026-39
Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation.
Garriock RJ, Chalamalasetty RB, Kennedy MW, Canizales LC, Lewandoski M, Yamaguchi TP
Development (Cambridge, England) 2015 May 1;142(9):1628-38
Development (Cambridge, England) 2015 May 1;142(9):1628-38
EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.
Miao H, Gale NW, Guo H, Qian J, Petty A, Kaspar J, Murphy AJ, Valenzuela DM, Yancopoulos G, Hambardzumyan D, Lathia JD, Rich JN, Lee J, Wang B
Oncogene 2015 Jan 29;34(5):558-67
Oncogene 2015 Jan 29;34(5):558-67
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM
Nature 2015 Apr 16;520(7547):363-7
Nature 2015 Apr 16;520(7547):363-7
Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones.
Iacopino F, Angelucci C, Piacentini R, Biamonte F, Mangiola A, Maira G, Grassi C, Sica G
PloS one 2014;9(8):e105166
PloS one 2014;9(8):e105166
Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.
Sousa-Ferreira L, Aveleira C, Botelho M, Álvaro AR, Pereira de Almeida L, Cavadas C
PloS one 2014;9(3):e88917
PloS one 2014;9(3):e88917
A single-cell and feeder-free culture system for monkey embryonic stem cells.
Ono T, Suzuki Y, Kato Y, Fujita R, Araki T, Yamashita T, Kato H, Torii R, Sato N
PloS one 2014;9(2):e88346
PloS one 2014;9(2):e88346
Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex.
Minamide R, Fujiwara K, Hasegawa K, Yoshikawa K
PloS one 2014;9(1):e84460
PloS one 2014;9(1):e84460
Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy.
Yan K, Wu Q, Yan DH, Lee CH, Rahim N, Tritschler I, DeVecchio J, Kalady MF, Hjelmeland AB, Rich JN
Genes & development 2014 May 15;28(10):1085-100
Genes & development 2014 May 15;28(10):1085-100
Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.
Onishi K, Tonge PD, Nagy A, Zandstra PW
Stem cell reports 2014 Jul 8;3(1):156-68
Stem cell reports 2014 Jul 8;3(1):156-68
The subventricular zone is able to respond to a demyelinating lesion after localized radiation.
Capilla-Gonzalez V, Guerrero-Cazares H, Bonsu JM, Gonzalez-Perez O, Achanta P, Wong J, Garcia-Verdugo JM, Quiñones-Hinojosa A
Stem cells (Dayton, Ohio) 2014 Jan;32(1):59-69
Stem cells (Dayton, Ohio) 2014 Jan;32(1):59-69
Chondroitin sulfate is indispensable for pluripotency and differentiation of mouse embryonic stem cells.
Izumikawa T, Sato B, Kitagawa H
Scientific reports 2014 Jan 15;4:3701
Scientific reports 2014 Jan 15;4:3701
Zrf1 is required to establish and maintain neural progenitor identity.
Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah SA, Graf T, Broccoli V, Di Croce L
Genes & development 2014 Jan 15;28(2):182-97
Genes & development 2014 Jan 15;28(2):182-97
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.
Volonté A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, Bissolati M, Ghirardelli L, Orsenigo E, Ferrone S, Doglioni C, Stassi G, Dellabona P, Staudacher C, Parmiani G, Maccalli C
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 1;192(1):523-32
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 1;192(1):523-32
Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape.
Sherwood RI, Hashimoto T, O'Donnell CW, Lewis S, Barkal AA, van Hoff JP, Karun V, Jaakkola T, Gifford DK
Nature biotechnology 2014 Feb;32(2):171-178
Nature biotechnology 2014 Feb;32(2):171-178
Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb.
Li T, Pan YW, Wang W, Abel G, Zou J, Xu L, Storm DR, Xia Z
PloS one 2013;8(4):e61948
PloS one 2013;8(4):e61948
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJ
Nature biotechnology 2013 May;31(5):426-33
Nature biotechnology 2013 May;31(5):426-33
Embryonic stem cell-based modeling of tau pathology in human neurons.
Mertens J, Stüber K, Poppe D, Doerr J, Ladewig J, Brüstle O, Koch P
The American journal of pathology 2013 May;182(5):1769-79
The American journal of pathology 2013 May;182(5):1769-79
Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus.
Haan N, Goodman T, Najdi-Samiei A, Stratford CM, Rice R, El Agha E, Bellusci S, Hajihosseini MK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 3;33(14):6170-80
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 3;33(14):6170-80
Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium.
Hayashi R, Ishikawa Y, Ito M, Kageyama T, Takashiba K, Fujioka T, Tsujikawa M, Miyoshi H, Yamato M, Nakamura Y, Nishida K
PloS one 2012;7(9):e45435
PloS one 2012;7(9):e45435
REST regulates oncogenic properties of glioblastoma stem cells.
Kamal MM, Sathyan P, Singh SK, Zinn PO, Marisetty AL, Liang S, Gumin J, El-Mesallamy HO, Suki D, Colman H, Fuller GN, Lang FF, Majumder S
Stem cells (Dayton, Ohio) 2012 Mar;30(3):405-14
Stem cells (Dayton, Ohio) 2012 Mar;30(3):405-14
Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells.
Lathia JD, Gallagher J, Myers JT, Li M, Vasanji A, McLendon RE, Hjelmeland AB, Huang AY, Rich JN
PloS one 2011;6(9):e24807
PloS one 2011;6(9):e24807
Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects.
Mahar I, Tan S, Davoli MA, Dominguez-Lopez S, Qiang C, Rachalski A, Turecki G, Mechawar N
PloS one 2011;6(10):e26610
PloS one 2011;6(10):e26610
Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells.
Kambal A, Mitchell G, Cary W, Gruenloh W, Jung Y, Kalomoiris S, Nacey C, McGee J, Lindsey M, Fury B, Bauer G, Nolta JA, Anderson JS
Molecular therapy : the journal of the American Society of Gene Therapy 2011 Mar;19(3):584-93
Molecular therapy : the journal of the American Society of Gene Therapy 2011 Mar;19(3):584-93
Human haploid cells differentiated from meiotic competent clonal germ cell lines that originated from embryonic stem cells.
West FD, Mumaw JL, Gallegos-Cardenas A, Young A, Stice SL
Stem cells and development 2011 Jun;20(6):1079-88
Stem cells and development 2011 Jun;20(6):1079-88
Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel.
Hibino N, Villalona G, Pietris N, Duncan DR, Schoffner A, Roh JD, Yi T, Dobrucki LW, Mejias D, Sawh-Martinez R, Harrington JK, Sinusas A, Krause DS, Kyriakides T, Saltzman WM, Pober JS, Shin'oka T, Breuer CK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Aug;25(8):2731-9
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Aug;25(8):2731-9
Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primary mediastinal germ cell tumors.
Liu A, Cheng L, Du J, Peng Y, Allan RW, Wei L, Li J, Cao D
The American journal of surgical pathology 2010 May;34(5):697-706
The American journal of surgical pathology 2010 May;34(5):697-706
Noninvasive imaging of endogenous neural stem cell mobilization in vivo using positron emission tomography.
Rueger MA, Backes H, Walberer M, Neumaier B, Ullrich R, Simard ML, Emig B, Fink GR, Hoehn M, Graf R, Schroeter M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 May 5;30(18):6454-60
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 May 5;30(18):6454-60
Paternal recognition of adult offspring mediated by newly generated CNS neurons.
Mak GK, Weiss S
Nature neuroscience 2010 Jun;13(6):753-8
Nature neuroscience 2010 Jun;13(6):753-8
Epigenetic changes to human umbilical cord blood cells cultured with three proteins indicate partial reprogramming to a pluripotent state.
Wong CJ, Casper RF, Rogers IM
Experimental cell research 2010 Apr 1;316(6):927-39
Experimental cell research 2010 Apr 1;316(6):927-39
Efficient serum-free derivation of oligodendrocyte precursors from neural stem cell-enriched cultures.
Rao RC, Boyd J, Padmanabhan R, Chenoweth JG, McKay RD
Stem cells (Dayton, Ohio) 2009 Jan;27(1):116-25
Stem cells (Dayton, Ohio) 2009 Jan;27(1):116-25
Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells.
Neganova I, Zhang X, Atkinson S, Lako M
Oncogene 2009 Jan 8;28(1):20-30
Oncogene 2009 Jan 8;28(1):20-30
The intracellular distribution of the ES cell totipotent markers OCT4 and Sox2 in adult stem cells differs dramatically according to commercial antibody used.
Zuk PA
Journal of cellular biochemistry 2009 Apr 1;106(5):867-77
Journal of cellular biochemistry 2009 Apr 1;106(5):867-77
Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria.
Günther HS, Schmidt NO, Phillips HS, Kemming D, Kharbanda S, Soriano R, Modrusan Z, Meissner H, Westphal M, Lamszus K
Oncogene 2008 May 1;27(20):2897-909
Oncogene 2008 May 1;27(20):2897-909
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL
Nature cell biology 2008 Jul;10(7):837-48
Nature cell biology 2008 Jul;10(7):837-48
Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.
Lathia JD, Okun E, Tang SC, Griffioen K, Cheng A, Mughal MR, Laryea G, Selvaraj PK, ffrench-Constant C, Magnus T, Arumugam TV, Mattson MP
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 17;28(51):13978-84
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 17;28(51):13978-84
Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue.
Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai J, Xu QX, Davidson BP, Stice SL, Smith AK, Goldman SA, Reubinoff BE, Zhan M, Rao MS, Chesnut JD
Stem cells (Dayton, Ohio) 2007 May;25(5):1298-306
Stem cells (Dayton, Ohio) 2007 May;25(5):1298-306
Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.
Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC
Stem cells (Dayton, Ohio) 2007 Jun;25(6):1511-20
Stem cells (Dayton, Ohio) 2007 Jun;25(6):1511-20
Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1.
Hattori Y, Ohta S, Hamada K, Yamada-Okabe H, Kanemura Y, Matsuzaki Y, Okano H, Kawakami Y, Toda M
Biochemical and biophysical research communications 2007 Dec 28;364(4):737-42
Biochemical and biophysical research communications 2007 Dec 28;364(4):737-42
Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy.
Schmitz M, Temme A, Senner V, Ebner R, Schwind S, Stevanovic S, Wehner R, Schackert G, Schackert HK, Fussel M, Bachmann M, Rieber EP, Weigle B
British journal of cancer 2007 Apr 23;96(8):1293-301
British journal of cancer 2007 Apr 23;96(8):1293-301
Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats.
Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O
Stroke 2006 Sep;37(9):2361-7
Stroke 2006 Sep;37(9):2361-7
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human SOX2 by Simple WesternTM. Simple Western lane view shows lysates of BG01V human embryonic stem cells, loaded at 0.2 mg/mL. A specific band was detected for SOX2 at approximately 50 kDa (as indicated) using 4 µg/mL of Mouse Anti-Human/Mouse/Rat SOX2 Monoclonal Antibody (Catalog # MAB2018). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human, Mouse, and Rat SOX2 by Western Blot. Western blot shows lysates of NTera-2 human testicular embryonic carcinoma cell line, F9 mouse teratocarcinoma stem cells, D3 mouse embryonic stem cell line, and rat cortical stem cells. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human/Mouse/Rat SOX2 Monoclonal Antibody (Catalog # MAB2018) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for SOX2 at approximately 36 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- E-Cadherin and SOX2 in BG01V Human Stem Cells. E-Cadherin and SOX2 were detected in BG01V human embryonic stem cells using 10 µg/mL Goat Anti-Human E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF648) and 10 µg/mL Mouse Anti-Human/Mouse/Rat SOX2 Monoclonal Antibody (Catalog # MAB2018). Cells were incubated with primary antibodies for 3 hours at room temperature. Cells were stained for E-Cadherin using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and for SOX2 using the NorthernLights 493-conjugated Anti-Mouse Secondary Antibody (green; Catalog # NL009). Cells were counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- SOX2 in BG01V Human Embryonic Stem Cells. SOX2 was detected in immersion fixed BG01V human embryonic stem cells using Mouse Anti-Human/ Mouse/Rat SOX2 Monoclonal Antibody (Catalog # MAB2018) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (yellow; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of SOX2 in NTera-2 Human Cell Line by Flow Cytometry. NTera-2 human testicular embryonic carcinoma cell line was stained with Mouse Anti-Human/ Mouse/Rat SOX2 Monoclonal Antibody (Catalog # MAB2018, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.
