HLA-DOB

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Description

Major histocompatibility complex, class II, DO beta

Tissue specificity

Group enriched (intestine, lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

6 (32812763 - 32820466)

Ensembl ID

ENSG00000241106  (ver. 103.38)

Orthologs

Mouse H2-Ob: ENSMUSG00000041538

UniProt

P13765

neXtProt

NX_P13765

Human splice variants
Mouse splice variants

Protein structure