EPPIN

This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Description

Epididymal peptidase inhibitor

Tissue specificity

Group enriched (epididymis, testis)

Predicted location

Intracellular, Secreted in male reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

20 (45540626 - 45547752)

Ensembl ID

ENSG00000101448  (ver. 103.38)

Orthologs

-

UniProt

O95925

neXtProt

NX_O95925

Human splice variants

Protein structure