DMABT-45242MG

antibody from Creative Diagnostics

Targeting: CD8A CD8

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

DMABT-45242MG

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DMABT-45242MG, RRID:AB_2394193

Product name

Anti-CD8 monoclonal antibody, clone DU7

Antibody type

Monoclonal

Description

CD8 is a 68 kDa disulphide-linked, transmembrane glycoprotein. The CD8 molecule serves as a receptor for MHC class I molecules and can mediate a function as a coreceptor in TCR-ligand binding and T-cell activation. Its cytoplasmic part is associated with the p56lck tyrosine kinase. CD8 is expressed by the great majority of cortical thymocytes and approximately 30% of medullary thymocytes, and by class I major histocompatibility complex restricted, mature suppressor/cytotoxic T cells. In addition a proportion of ÎÛÑ´ T cells and NK cells express CD8. Thus, CD8 is expressed by about 25-35% of peripheral T cells, and about 30% of NK cells express low levels of CD8. Immunophenotyping of lymphocytes is widely applied as a component of the testing of peripheral blood for diagnosis of immunodeficiencies such as aquired immunodeficiency syndrome (AIDS). An increase in the percentage of CD8-positive T cells has been reported during cytomegalovirus infection.

Reactivity

Guinea Pig

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

DU7

Vial size

250 _l

Concentration

IgG concentration 1.0 mg/ml

Storage

Store at +4 oC or at -20 oC if preferred.This product should be stored undiluted.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.