301002

antibody from BioLegend

Targeting: CD8A CD8

Immunohistochemistry

Antibody data

Submit

Validation data

Product number: 301002 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#301002, RRID:AB_314120
Product name: Purified anti-human CD8a
Antibody type: Monoclonal
Antigen: CD8a
Description: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Reactivity: Human, Simian
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4° C.

CD8A protein structure - 301002 shown in red.