TNFRSF6B

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Description

TNF receptor superfamily member 6b

Tissue specificity

Tissue enhanced (lung)

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

20 (63696652 - 63698684)

Ensembl ID

ENSG00000243509  (ver. 103.38)

Orthologs

-

UniProt

O95407

neXtProt

NX_O95407

Human splice variants

Protein structure