INMT

N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]

Description

Indolethylamine N-methyltransferase

Tissue specificity

Tissue enhanced (lung)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

7 (30697985 - 30757602)

Ensembl ID

ENSG00000241644  (ver. 103.38)

Orthologs

-

UniProt

O95050

neXtProt

NX_O95050

Human splice variants

Protein structure