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MYC
MYC proto-oncogene, bHLH transcription factorbHLHe39, c-Myc, MYCC
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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| Invitrogen Antibodies |  13-2500 |
152 references | Monoclonal |
WB
EL
ICC
IP
IHC
GS
ChIP
OA
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| Novus Biologicals | NB600-302 |
33 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
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| Proteintech Group | 10828-1-AP |
314 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| GeneTex | GTX20032 |
11 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
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| antibodies-online | ABIN153225 |
26 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
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